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KMID : 0606920080160040431
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Biomolecules & Therapeutics
2008 Volume.16 No. 4 p.431 ~ p.436
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A Comparison of Gene Expression Profiles between Primary Human AML Cells and Therapy-related AML Cells
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Kim Young-Hun
Kim Hyung-Soo
Hwang Jun-Mo
Lee Jin-Seok
Kim Seong-Gon
Park So-young
Chang Kyu-Tae
Kim Kil-Soo
Ryoo Zae-Young
Lee Sang-Gyu
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Abstract
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To identify genes whose expression correlated with biological features of therapy-related AML (t-AML), we analyzed the expression profiles of de novo AML t(9;11) and t-AML t(9;11) bone marrow samples using previously published SAGE data. Three-hundred twenty-nine transcripts that satisfied statistical (P<0.05) and magnitude-of-change ( 4-fold) criteria were identified as differentially expressed between de novo AML t(9;11) and t-AML t(9;11) cells. Of these transcripts, 301 (91%) matched known genes or ESTs and were classified according to functional categories (http://david.abcc.ncifcrf.gov/). The majority of differentially expressed genes in t-AML t(9;11) were involved in the regulation of biological and metabolic processes. Especially prominent among these were genes related to immune and drug responses. These results establish a framework for developing new drugs for the treatment of t-AML.
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KEYWORD
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Therapy-related AML, Gene expression, SAGE
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